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大气细颗粒物PM_(2.5)对人脐静脉内皮细胞蛋白质组的影响(...  CNKI文献

目的:应用双向电泳及质谱技术分析对人脐静脉内皮细胞(HUVEC)蛋白质组的影响,探讨引起心血管毒性的潜在机制。创新点:多项流行病学调查表明,与人类心血管疾病有密切关系,而血管内皮细胞是血管的第一道防线。本项目应用...

Ji ZHU Lin-wen-si ZHU... 《Journal of Zhejiang University-Science B(Biomedicine & ...》 2018年06期 期刊

关键词: PM2.5 / 人脐静脉内皮细胞 / 蛋白质组 / 毒性机制

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Diabetic nephropathy and inflammation  CNKI文献

Diabetic nephropathy(DN) is the leading cause of end-stage renal failure worldwide. Besides, diabetic nephropathy is associated with cardiovascular disease, and increases mortality of diabetic patien...

Montserrat B Duran-Salgado Alberto F Rubio-Guerra 《World Journal of Diabetes》 2014年03期 期刊

关键词: Diabetic / Nephropathy / Inflammation / Albuminuria

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Circular RNA ciRS-7 promotes the proliferation and met...  CNKI文献

Background: Pancreatic ductal adenocarcinoma(PDAC) is the most deadly type of tumor, and its pathogenesis remains unknown. Circular RNAs(circRNAs) may be functional and bind to micro RNAs and consequ...

Lei Liu Fu-Bao Liu... 《Hepatobiliary & Pancreatic Diseases International》 2019年06期 期刊

关键词: ciRS-7 / miR-7 / EGFR/STAT3 / pathway

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Baicalin extracted from Huangqin(Radix Scutellariae Ba...  CNKI文献

OBJECTIVE:To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.METHODS:Cell proliferation an...

Wang Hongwei Li Hailong... 《Journal of Traditional Chinese Medicine》 2017年02期 期刊

关键词: Baicalin / Stomach / neoplasms / Apoptosis

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绿茶多酚表没食子儿茶素没食子酸酯(EGCG)体外对抗乙肝病毒...  CNKI文献

研究目的:乙肝是尚未解决的公众健康问题,需要开发新型抗病毒药物。本研究拟从天然植物绿茶中寻找有效、经济、毒副作用低的抗乙肝病毒药物。创新要点:首次以HepG2 2.2.15细胞为载体,发现EGCG对乙肝病毒HBsAg、HBeAg和...

Jing-yao PANG Kui-jun ZHAO... 《Journal of Zhejiang University-Science B(Biomedicine & ...》 2014年06期 期刊

关键词: EGCG / 乙肝病毒(HBV) / 抗病毒 / HepG2

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Current status of in vivo bioanalysis of nano drug del...  CNKI文献

The development of nano drug delivery systems(NDDSs) provides new approaches to fighting against diseases.The NDDSs are specially designed to serve as carriers for the delivery of active pharmaceutic...

Tingting Wang Di Zhang... 《Journal of Pharmaceutical Analysis》 2020年03期 期刊

关键词: NDDSs / Polymer / Methodology / Pharmacokinetics

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Brain pathways of pain empathy activated by pained fac...  CNKI文献

OBJECTIVE: The objective of this study is to summarize and analyze the brain signal patterns of empathy for pain caused by facial expressions of pain utilizing activation likelihood estimation, a met...

Ruo-Chu Xiong Xin Fu... 《Neural Regeneration Research》 2019年01期 期刊

关键词: nerve / regeneration / facial / expression

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Acacetin protects against cerebral ischemia-reperfusio...  CNKI文献

Acacetin(5,7-dihydroxy-4′-methoxyflavone), a potential neuroprotective agent, has an inhibitory effect on lipopolysaccharide-induced neuroinflammatory reactions. However, whether acacetin has an eff...

Juan Bu Shen Shi... 《Neural Regeneration Research》 2019年04期 期刊

关键词: nerve / regeneration / acacetin / cerebral

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Genome-wide MicroRNA Expression Profiles in COPD: Earl...  CNKI文献

Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease...

Andreas Keller Tobias Fehlmann... 《Genomics,Proteomics & Bioinformatics》 2018年03期 期刊

关键词: microRNA / Cancer / COPD / Lung

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Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK...  CNKI文献

Objective: To investigate the effect of gambogic acid(GA) on the growth and cell death of castrate resistant prostate cancer(PC) with phosphate and tension homology(PTEN) and p53 genes deleted in vit...

PAN Hong LU Li-yuan... 《Chinese Journal of Integrative Medicine》 2018年02期 期刊

关键词: gambogic / acid / prostate / cancer

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Interleukin-6 compared to the other Th17/Treg related ...  CNKI文献

BACKGROUND The connection between inflammatory bowel disease(IBD) and colorectal cancer(CRC) is well-established, as persistent intestinal inflammation plays a substantial role in both disorders. Cyt...

Tsvetelina Veselinova Velikova Lyuba Miteva... 《World Journal of Gastroenterology》 2020年16期 期刊

关键词: Inflammatory / bowel / disease / Colorectal

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Synergistic Effects of Chuanxiong-Chishao Herb-Pair on...  CNKI文献

Objective: To investigate the synergistic effects of Chuanxiong-Chishao herb-pair(CCHP) on promoting angiogenesis in silico and in vivo. Methods: The mechanisms of action of an herb-pair, ChuanxiongC...

WANG Yan GUO Gang... 《Chinese Journal of Integrative Medicine》 2017年09期 期刊

关键词: tetramethylpyrazine / paeoniflorin / angiogenesis / network

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Development of a Novel Reverse Transcription Loop-Medi...  CNKI文献

Dear Editor,Since early December 2019, a large outbreak of pneumonia caused by a novel coronavirus(COVID-19) had emerged in Wuhan, China(Wu et al. 2020 a, b; Zhou et al. 2020; Zhu et al. 2020; Jiang ...

Renfei Lu Xiuming Wu... 《Virologica Sinica》 2020年03期 期刊

关键词: Development / of / a / Novel

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Expression and localization of absent in melanoma 2 in...  CNKI文献

In traumatic brain injury, absent in melanoma 2(AIM2) has been demonstrated to be involved in pyroptotic neuronal cell death. Although the pathophysiological mechanism of spinal cord injury is simila...

Sai-Nan Wang Xue-Yan Guo... 《Neural Regeneration Research》 2019年03期 期刊

关键词: nerve / regeneration / spinal / cord

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Validation of aspartate aminotransferase to platelet r...  CNKI文献

AIM: To validate the value of aspartate aminotransferase to platelet ratio index(APRI) in assessment of liver fibrosis and prediction of postoperative prognosis of biliary atresia(BA) infants from Ma...

Li-Yuan Yang Jie Fu... 《World Journal of Gastroenterology》 2015年19期 期刊

关键词: Aspartate / aminotransferase / to / platelet

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MicroRNAs in colorectal cancer as markers and targets:...  CNKI文献

MicroRNAs are evolutionarily conserved small noncoding RNA molecules encoded by eukaryotic genomic DNA,and function in post-transcriptional regulation of gene expression via base-pairing with complem...

Jing-Jia Ye Jiang Cao 《World Journal of Gastroenterology》 2014年15期 期刊

关键词: MicroRNA / Epigenetic / modification / Colorectal

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Actively priming autophagic cell death with novel tran...  CNKI文献

Recently, considerable attention in the field of cancer therapy has been focused on the mammalian rapamycin target(m TOR), inhibition of which could result in autophagic cell death(ACD). Though novel...

Dong Mei Binlong Chen... 《Acta Pharmaceutica Sinica B》 2019年05期 期刊

关键词: Autophagic / cell / death / Combination

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Paeoniflorin Promotes Angiogenesis in A Vascular Insuf...  CNKI文献

Objective: To investigate the pro-angiogenic effects of paeoniflorin(PF) in a vascular insufficiency model of zebrafish and in human umbilical vein endothelial cells(HUVECs). Methods: In vivo, the pr...

XIN Qi-qi YANG Bin-rui... 《Chinese Journal of Integrative Medicine》 2018年07期 期刊

关键词: angiogenesis / paeoniflorin / zebrafish / human

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Clinical efficacy and safety of Traditional Chinese Me...  CNKI文献

OBJECTIVE: To observe the clinical efficacy and safety of Traditional Chinese Medicine(TCM) combined with Western Medicine(WM) in patients with diabetic acute ischemic stroke.METHODS: Ninety patients...

Huan Zhao Dongdong Yang... 《Journal of Traditional Chinese Medicine》 2014年02期 期刊

关键词: Diabetes / complications / Stroke / Treatment

下载(79)| 被引(9)

Efficacy of combined therapy in patients with hepatiti...  CNKI文献

AIM: To investigate the efficacy and safety of combined de novo lamivudine (LAM) and adefovir dipivoxil (ADV) therapy in hepatitis B virus (HBV)-related decompensated liver cirrhosis patients. METHOD...

Guo-Cai Lv Jin-Mei Yao... 《World Journal of Gastroenterology》 2013年22期 期刊

关键词: Liver / cirrhosis / Lamivudine / Adefovir

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