The mechanism regulating proteasomal activity under proteotoxic stress conditions remains unclear. Here, we showed that arsenite-induced proteotoxic stress resulted in upregulation of Arabidopsis hom...
Abnormal protein expression or activities are associated with many diseases,especially cancer.Therefore,down-regulating the proteins involved in cancer cell survival proved to be an effective strateg...
The COP9 signalosome(CSN) is a conserved protein complex, typically composed of eight subunits(designated as CSN1 to CSN8) in higher eukaryotes such as plants and animals, but of fewer subunits...
Cellular protein homeostasis is maintained by protein synthesis,correct protein folding and efficient proteolysis.Two ATP-consuming molecular machines help balance these processes: TRiC and proteasom...
Molecular pathogenesis studies of multiple myeloma(MM) have focused on coding genes rather than long non-coding RNAs(IncRNAs).However,evidence indicates that IncRNAs are involved in the initiation an...
