Inferring Gene Regulatory Network for Cell Reprogrammi...  CNKI文献

The remarkable discovery of induced pluripotent stem cells(iPSCs) demonstrates that cell can be reprogrammed from somatic cell to a pluripotent state by the enforced expression of defined transcripti...

DUREN Zhana SAITO Shigeru... 第三十一届中国控制会议论文集D卷 2012-07-25 国际会议

Drug Repositioning by a Computational Approach: Two Su...  CNKI文献

We discovered two drug candidates for prostate and breast cancers, which are resistant to each of base anticancer drugs, by using a computational approach. The drug for prostate cancer resistant to d...

Katsuhisa Horimoto 2016第十四届国际新药发明科技年会——2016第六届药物递送技... 2016-11-16 国际会议

An Integrated Gene Regulatory Network Inference Pipeli...  CNKI文献

Rapidly accumulated gene expression data put forward the development of numerous methods for inferring gene regulatory networks and the efforts for critical performance assessment of these methods.In...

HORIMOTO Katsuhisa 中国自动化学会控制理论专业委员会A卷 2011-07-22 中国会议

On Two Issues of Molecular Network Models in Systems B...  CNKI文献

Two points are definitely different between network models in systems biology and those in engineering fields. One is that most network models (structures) in biology are not static but change depend...

Katsuhisa Horimoto Proceedings of the Tenth International Symposium on Ope... 2011-08-28 国际会议

Potential Linkages Between the Inner and Outer Cellula...  CNKI文献

We analyzed both RNA profile to reveal gene expression changes and glycan profile to identify structural changes in glycans between four parental somatic cell (SC) lines and nine hiPSC lines that wer...

Shigeru Saito Yasuko Onuma... Proceedings of the Fourth International Conference on C... 2010-09-09 国际会议

Significant Regulatory Networks from Goto-Kakizaki Rat...  CNKI文献

In the aim of identifying significant transcriptional regulatory networks in the liver contributing to diabetes, we have performed comprehensive active regulatory network survey by network screening ...

Huarong Zhou Shigeru Saito... Proceedings of the Fourth International Conference on C... 2010-09-09 国际会议

Parameter Optimization in Network Dynamics Including U...  CNKI文献

In this report,we propose a new symbolic-numeric method of differential algebra and a numerical parameter optimization algorithm.First,we utilize differential elimination,which is an algebraic approa...

Masahiko Nakatsui Katsuhisa Horimoto Proceedings of the Third International Symposium on Opt... 2009-09-20 国际会议

An Algebraic-Numeric Algorithm for the Model Selection...  CNKI文献

Recently, we have proposed a novel algorithm to select a model that is the most consistent with the time series of observed data. In the algorithm, first, a system of differential equations that expr...

Masahiko Nakatsui Hiroshi Yoshida... Proceedings of the Second International Symposium on Op... 2008-10-31 国际会议

Detection of network structure changes by graphical ch...  CNKI文献

One of the most characteristic features of biological molecular networks is that the network structure itself changes, depending on the cellular environment. Indeed, activated molecules show a variet...

Shigeru Saito Masao Honda... Proceedings of Joint 48th IEEE Conference on Decision a... 2009-12-16 国际会议

Analysis of network dynamics including hidden variable...  CNKI文献

We propose a symbolic-numeric method for estimating the kinetic constants in a biological network including hidden variables which mean that the behaviors of corresponding molecules cannot be directl...

Daisuke Tominaga Yasuhito Tokumoto... Proceedings of the Second International Symposium on Op... 2008-10-31 国际会议

Integer Programming-based Approach to Allocation of Re...  CNKI文献

Observing behaviors of protein pathways and genetic networks under various environments in living cells is essential for unraveling disease and developing drugs. For that purpose, the biological expe...

Morihiro Hayashida Fuyan Sun... Proceedings of the First International Symposium on Opt... 2007-08-08 国际会议

Revealing Disease Related Interactions by Correlation ...  CNKI文献

The computational identification of disease related lesions is still a key open problem in biomedicine and systems biology. Dysregulated interactions may be an important reason that causes disease. I...

Zi-Kai Wu Zhi-Yong Zhang... Proceedings of the Second International Symposium on Op... 2008-10-31 国际会议

Genomic platform for efficient identification of funga...  CNKI文献

Fungal secondary metabolites(SMs) are structurally diverse natural compounds,which are thought to have a great potential not only for medical industry but also for chemical and environmental industri...

Myco Umemura Hideaki Koike... Proceedings of Asian Mycological Congress 2013 and the ... 2013-08-19 国际会议

Time Series Segmentation for Gene Regulatory Process w...  CNKI文献

Many important Biological processes fall into different successive phases with piecewise time varying structures. To reveal the sequential regulatory relationship between different phases, time serie...

Zhi-Yong Zhang Katsuhisa Horimoto... Proceedings of the Second International Symposium on Op... 2008-10-31 国际会议

Phase Shifts of Circadian Transcripts in Rat Suprachia...  CNKI文献

We analyzed the phase shifts of oscillated transcripts relative to the timing of phase-reset stimuli. Oscillations in gene expression profiles were extracted using the fast Fourier transform and fitt...

Ryoko Morioka Masanori Arita... Proceedings of the Second International Symposium on Op... 2008-10-31 国际会议

System Identification Models for Gene Regulation Syste...  CNKI文献

Recent bio-technologies enable us to successfully discover the functional organization of a cell by simultaneously measuring the dynamic change of concentrations of thousands of bio-molecules after s...

HORIMOTO Katsuhisa 第二十九届中国控制会议论文集 2010-07-29 中国会议

MECHANICAL AND GAS BARRIER PROPERTIES OF POLYOLEFIN/EV...  CNKI文献

Ethylene vinyl alcohol copolymer(EVOH) is known as a high oxygen barrier material and widely used in various kinds of packaging films because it can prevent the contents like foods and cosmetics from...

Kouki MORITA Hiroki TAKESHITA... EIGHTH INTERNATIONAL SYMPOSIUM ON ENGINEERING PLASTICS ... 2017-08-08 国际会议

Two-phase crystallization and dopant distribution in g...  CNKI文献

White light emitting diodes(WLEDs)have attracted much attention in various areas including illumination and display.However,organic binders for phosphor encapsulation easily degrade with UV irradiati...

Yuan Gao Shusuke Murai... 第十届中国功能玻璃学术研讨会暨新型光电子材料国际论坛会议... 2018-11-08 国际会议

Tanaka Laboratory(Industrial Solid-State Chemistry)  CNKI文献

In recent years,many breakthroughs have been achieved in the area of inorganic materials,such as the discovery and invention of quasi-crystals,high-Tc superconductors,colossal magnetoresistive materi...

Katsuhisa Tanaka Shunsuke Murai... 第十届中国功能玻璃学术研讨会暨新型光电子材料国际论坛会议... 2018-11-08 国际会议

MECHANICAL AND THERMAL PROPERTIES OF POLYLACTIC ACID W...  CNKI文献

In this study,we prepared several cellulose nano-fiber(CNF) by Cardo material(BPFG) shown in Fig.1(a),referred to as B-CNF,with various degrees of substitution to BPFG.Moreover,we also prepared the C...

Katsuhisa TOKUMITSU Shinya KATSURADA... EIGHTH INTERNATIONAL SYMPOSIUM ON ENGINEERING PLASTICS ... 2017-08-08 国际会议